Conference Day One: Tuesday 19th May 2009

8.45 Pharma IQ Welcome

8.50 Chairperson Opening Remarks

Dr. Terry Wood
Head of Liquid Store Centre of Emphasis
Pfizer Global R&D

9.00 Developing A Global Biologics Registration System

• Defining biological entities and their rules for uniqueness; tracking the lineage of an entity and the relationships between entities
• Understanding and supporting diverse workflows across projects and sites
• Integrating with other Drug Discovery applications
• The Special Interest Group (SIG) model for collaborative development: Minimising project risks and costs
• Next phase: Global Biologics Inventory System for sample tracking, storage, dispersals and automation

Joseph M. Cesarone, Ph.D.
Principal Research Computer Scientist, Scientific Informatics & Automation
Abbott Laboratories

9.45 Supporting Your Compound Management Processes With A Flexible IT Framework

• Setting up your IT backbone to interface with automated, semi-automated or manual stores
• How to interface with your lab devices (scales, pipettes, …)
• Managing your inventory, orders, processes with smooth workflows
• Creating a more flexible IT framework to interface with your existing infrastructure
• Harmonising your heterogeneous environment within single labs or between your different global sites

Stéphanie Muzzarelli
Manager, Compound Management
Logica Switzerland AG

Track A – QC and Analytics	Track B – Nano and CM
Track Chair: Dr. Till Kühn Product Manager Bruker BioSpin AG	Track Chair: Dr. Terry Wood Head of Liquid Store Centre of Emphasis Pfizer Global R&D
11.00 Quality Control And Concentration Determination Of Compound Libraries By Combined NMR And LC-UV-MS Analytics Gauging and comparing the reliability of existing concentration detectors Using analytical quality control data to feed into assay interpretation Increasing throughput of analytical characterisation to keep up with demand Evaluating precision of different tools for concentration determination by NMR Dr. Götz Schlotterbeck Scientific Specialist Hoffmann La Roche	11.00 Implementing Acoustic Dispensing From 1536 Source Plates Within Compound Management GSK has implemented a number of different platforms based on using low volume acoustic dispensing technology to meet different needs of Compound Management customers. This presentation will cover the selection of appropriate hardware and IT systems for the differing needs, and the practical issues faced in their implementation. 1536 source plate storage Keeping operators in control Use of multiple acoustic dispensers Process flexibility and data tracking Neil Hardy Project Manager, Compound Management GlaxoSmithKline
11.45 Multiplexed LC/MS Systems For High Throughput Sample Analysis With Minimal Operator Expertise Understanding how an automated analysis system used with a sample plate delivery system and multiple LC/MS systems can be used for determining compound purity in pharmaceutical libraries Automated sample preparations - How just-in-time delivery of a plate to the next available LC/MS system works Monitoring the chromatographic and mass spectroscopic performance, as well as solvent and column usage Ensuring successful analysis, minimal routine and triggered maintenance with little specialist expertise required Examples of how to ensure maximum sample throughput with robust analyses Dr. Tony Brand Solutions Application Scientist Agilent Technologies	11.45 Practical Realities Of Using A High Throughput Cherry Picking (HTCP) Module To Support New Screening Paradigms Design of the HTCP system based on acoustic dispensing Integration of the new system in the HTS workflow Outlining new opportunities with the HTCP module Examples of flexible experimental design enabled by HTCP picking capabilities Caroline Engeloch Research Investigator, Compound Management Novartis
12.30 Networking Lunch Break
13.30 Balancing The Use Of LC-MS, ELSD And NMR To Assess And Quantify Compound Integrity For Chemists And Compound Management Balancing the overall efforts in HT LC/MS and low volume NMR to compound management QC Action and communication of results Handling mistakes and errors Optimising the costs and data management in low volume tube NMR Future directions: UPLC detection for faster analysis and lower sample amounts. Improved quality of NMR spectra Dr. Henrik Pedersen Head, Compound ID & Purification Lundbeck	13.30 Supporting Successful Hit Finding With Cost-Effective 1535 Plate Nano-Dispensing How we are using 1536 plates to support to hit finding efforts Assessing the benefits of using new desealers Implementing an innovative washing technique to minimise the use of DMSO Testing the value of recycling of plates Philippa Skinner Compound Management, Lead Generation AstraZeneca Mölndal
14.15 Panel Discussion: Guaranteeing Quality Compounds: Minimising CM Efforts Whilst Assuring Chemists By Delivering A Quality Certificate Educating chemists on stock solutions Overcoming cultural differences and views Reducing time and process by implementing quality guarantee certificates All speakers and participants of Track A are invited to join this discussion	14.15 Panel Discussion: What Will Sample Management And Dispensing Technology Look Like In 5 Years? Acoustic dispensing: How CM is evolving into a science and how to continue to be prepared Examining shelf life of plates Addressing the quality of biological data Tubes vs. plates: How to create a micro environment with little air around compound What assay platforms and dispensing technology will we see emerge as most successful in 5-10 years? Automation and high-throughput: What will we have to be ready for in 5 years? All speakers and participants of Track B are invited to join this discussion
15.00 Networking Coffee Break

15.30 Roundtable Best Practice Discussions

During each roundtable, the facilitator will present a short case study as a benchmark for a 60 minute discussion and question session. Attendees will get a comprehensive review of the surrounding issues, technical capabilities and differing end-user views. You will also get answers to many questions and new innovative ideas to take back and apply to your compound management work.

**Delegates are welcome and encouraged to bring their own data or study results or submit them earlier to courtney.becker@iqpc.co.uk

A) Compound Purity and Quality Profiling
B) Outsourcing Your Compound Management Activities
C) Automated Weighing Tools
D) Compound Data Integration Post-Merger
E) Comparing New Screening Approaches to Cycle Times: Have they Improved?
F) Tubes vs. Plates: Examining Storage Formats

16.30 Summaries Of Roundtable Discussions

Each Roundtable Discussion will be summarised so all delegates can learn the most interesting and valuable points to each discussion subject.

17.10 Chairperson’s Closing Remarks

17.30 Networking Drinks And Announcement Of Compound Manager Of The Year 2009 Award

18.45 – 21.45 Workshop B: Building Effective Local And Global Compound Management Operations Using A Dedicated Business Process Management Framework

Dinner served during workshop

Compound Management is always facing the trade-off between flexibility and costs, as higher flexibility means higher costs. This leads to the compelling idea of utilising the flexibility of a business process management platform and combine this with a solid foundation of predefined workflows and processes which are common in compound management solutions. In the first half of this workshop, we will give an insight into the framework, and share some of the critical design decisions and lessons learned on the way. A demo of a real-life workflow from one of our customers will serve to get a feeling of how all this works together. The second half of the workshop we will do some hands-on work developing a new or adapted real-life workflow, ideally taken from the audience. At the end of the workshop, all participants will have a solid overview of the benefits (and limitations) of a BPM based framework approach to compound management.

Attend this workshop to:

• Understand how a Business Process Management System can be used to build CM solutions
• Learn about the proper granularity of services composing CM workflows
• Examine key design decisions and lessons learned
• Understand the key arguments to get funding for a BPM based solution

Workshop Leader:

Stéphanie Muzzarelli
Manager, Compound Management
Logica Switzerland AG

[ Register Now ] · [ Next: Conference Day Two: Wednesday 20th May 2009 ]