Outsourcing Focus Day: Monday 18th May 2009
Outsourcing and Sourcing Compounds
10.00 Registration And Coffee
10.30 Opening Remarks From Chairperson
10.45 Johnson & Johnson Case Study: Outsourcing The US Compound Collection
- Drivers for outsourcing collection and objectives
- Internal discussions and issues overcome: To make a back up copy or not?
- Outsourcing liquid handling, QC and all neat compounds while maintaining efficient turnaround for world-wide ordering
- Developing a clear SOP for efficient processes: Issues for setting up outsourcing with service provider
- Maintenance of our local store of <10,000 compounds for high demand, recently synthesised compounds
- Improving quality of compound store by QC incoming compounds to avoid mis-registrations
- Did we achieve what we set out to do? Have we lowered our costs? What do we do next?
Dr. Gary Caldwel
Senior Research Fellow, Enabling Technology, Drug Discovery
Johnson & Johnson Pharmaceutical Research and Development
11.30 Compound Management Outsourcing Case Study: The US National Institute Of Health Molecular Libraries Small Molecule Repository
Since 2004, the US National Institutes of Health (NIH) Molecular Libraries Small Molecule Repository (MLSMR) has built and distributed a collection of more than 300,000 compounds to a network of 12 HTS screening centers. NIH outsourced MLSMR to BioFocus DPI. What were NIH’s considerations in selecting a partner for outsourcing, what challenges has MLSMR faced, and what has outsourced compound management delivered to NIH?
- The NIH Molecular Libraries Program and the decision to outsource CM
- Collaborating with BioFocus DPI to identify, select, and acquire the MLSMR collection
- NIH’s choices for sample QC, processing, storage, and plating
- Managing the many-way relationship between NIH, BioFocus DPI, and 12 HTS screening centers
- Coordinating data between MLSMR and the screening centers, and making it publicly available
Jamie Driscoll
Chief of Research Services, Division of Neuroscience and Basic Behavioral Science
National Institute of Mental Health
12.15 Networking Lunch Break
13.15 Assessing Outsourcing Opportunities For Compound Management And Compound Sourcing
- Compound Management & Sourcing within the new Nycomed Discovery Organisation
- The Nycomed way: Connecting internal research sites in Konstanz, Hamburg and Mumbai
- Creating win-win situations with our partners
- Monitoring external performances and quality
Dr. Matthias Vennemann
Head of Compound Management & Sourcing, Global Medicinal Chemistry
Nycomed GmbH
14.00 Assessing Diversity And Drug Likeness For A General Purpose Screening Library Built From Commercial Sources
- Qualifying external sources for quality compounds
- Collaborating with medicinal chemistry to develop a set of rules to identify suitable compound categories
- Coping with resource constraints
- Experiences with compounds vendors: Lessons learned
Dr. Adrian Brüngger-Brecht
Head of Discovery Informatics
Basilea Pharmaceutica International AG
14.45 Networking Coffee Break
15.15 Panel Discussion: Examining Models Of Outsourcing Compound Management And Financial Comparisons
- Examining opportunities for outsourcing
- When a company needs to update CM facilities and equipment
- Post-merger or post-corporate re-structuring
- SME needs for balancing cost and increasing efficiency
- Working with ‘chemistry collaborators’ and dealing with increasing number of compounds and shipments coming in from various international
- Examining service providers: Academia vs. Commercial Contract Service Providers
Panelists:
16.30 Closing Remarks
17.30 – 20.30 Workshop A: Leveraging Advanced Technology to Optimise Compound Management and Integrity of Results
Dinner served during workshop
Today’s compound managers and researchers are under growing pressure to increase their outputs, and throughputs correspondingly. The role of technology (both hardware and software) in achieving these advancements has never been greater. This workshop will work through examples of how you can use advanced technology to accelerate compound management operations and drug discovery decision making. Through presentations and interactive work sessions, participants will learn how they can:
- Implement innovative docking technology to make their laboratory hardware investment both flexible and sustainable, and to allow materials and equipment to link up with downstream drug discovery activities
- Use different system enclosure options to protect the integrity of their samples
- Customise scheduling software to interface with inventory management vendors (including Remp and Titian) to best match their workflow
- Use scheduling software to track liquids, creating customised replication logs for multiple liquid handling vendors (including EDC, Labcyte and Hamilton)
- Apply HighRes’ new cherry picking dose response functionality to a wide range of liquid delivery mechanisms.
We will also include a case study of how this advanced technology is being utilised at the Broad Institute’s Chemical Biology Platform. This facility, designed and supplied by HighRes Biosolutions, offers “Drug Discovery in a Room”, starting from dry powder compound stores, materials and equipment flow through the five distinct robotic systems, working from compound management right through to biological results in a plate reader.
This workshop is designed to be relevant both for people working in large pharmaceutical companies with established compound management facilities, and smaller operations like biotech companies and academic research laboratories that are still finalising their hardware and software set-ups.
Workshop Leader:
Jack Dawson
European Applications Manager
HighRes Biosolutions
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