Conference Day One: 18th May 2010
Creating Flexible, Process Driven CM Operations to Meet Evolving Screening Strategies and Customer Demands
08.30 Registration And Coffee
09.15 Pharma IQ’s Welcome And Opening Remarks From Conference Chairperson
Terry Wood
Head of Liquid Store Centre of Emphasis
Pfizer Global R&D
09.20 Opening Keynote Address: History Of Compound Management: Learning
How Far We’ve Come In Managing Tomorrow’s Medicines
- A short but eventful walk down memory lane
- Rapid technical developments
- Contributing to revolutionary science and tomorrow’s medical cures
Terry Wood
Head of Liquid Store Centre of Emphasis
Pfizer Global R&D
10.00 Supporting Both HTS And Multiple Hit Strategies With
Flexible Processes: A GSK Case Study
- Running an effective Compound Management lab to support Hit Discovery activities
- Exploiting cutting-edge technology for increased quality, performance and capability
- Supplying the same quantity of compounds while ensuring the same level of quality
- Keeping up with the demands of customers to deliver focused screening sets
- Adapting our processes with customers to provide "customised sets" with often different plate and compound formats
- Next steps for Sample Management at Tres Cantos and GSK Europe
Lola Jimenez-Alfaro
Manager, Sample Management Technologies
GlaxoSmithKline
10.40 Morning Networking Break
11.10 Experiences From Reorganising Actelion's CM Workflow:
Implementing New Systems And Processes To Optimally
Support The Drug Discovery Process
- Rethinking the HTS and CM strategy in a rapidly growing organisation
- Centralising solution sample production: QC, speed, and user friendliness
- The screening library: Structural evolution and physical turn-over, storage and access
- Producing assay-ready plates for HTS: Medium throughput, medium volumes, but full process integration
- The human factor: Managing the development project, getting change accepted, growing with the task
- Future directions: Compound transfer, concentration determination, biosample management
Oliver Peter
Senior Lab Head, Drug Discovery Biology, HTS Group
Actelion Pharmaceuticals Ltd
11.50 A High Throughput Approach To Delivering Compounds
To Evolving Drug Discovery Departments
As the demand for compounds used in Pharmaceutical Discovery continues
to escalate, manual dispensing of compounds is no longer capable of
keeping pace. The use of pre-configured plates of compounds solvated in
DMSO lends itself to high-throughput automation, but is limited by its
inability to easily support cherry-picking of individual compounds, especially
when servicing requests containing large numbers of items, and the need to
store solvated compounds frozen to extend shelf-life to reasonable durations
requires undesirable freeze-thaw-freeze cycles for plate replication with this
approach. In this presentation, Robert will discuss how Abbott has addressed
these issues, including:
- A high-throughput cherry-picking storage and retrieval system that contains multiple copies of each compound in pre-formatted aliquots that can be retrieved at a rate of up to 50,000 per day
- Providing samples to HTS, Hit-to-Lead, High Throughput ADME, the SAR by NMR group, and other Discovery groups that will enable much larger experiments than were previously possible
- Examining the requirements and decisions that led to the design of the system
- Discussing outcomes of how the system has allowed for entirely new screening paradigms within the HTS organisation
- Overcoming technical challenges to get the system ready for production use
Robert Schmitt
Manager, Molecular Services, GPRD Advanced Technology
Abbott Laboratories
12.30 User-Driven Sample Management Vertex Case Study: Implementing New Processes And Systems For A Global Archive
- Background to revamping Vertex’s liquid and solid stores with new hardware and software
- A new user interface to support data driven compound ordering and management
- Allowing user-driven customisation without adding manual work or liquid handling protocol customisation
- Incorporating data tracking for assay ready plates
- Next: Building in analytical capabilities and predictive quality measures
Sarah Steklov
Group Leader, Discovery Operations
Vertex Pharmaceuticals
13.10 Networking Lunch
TRACK A: Using the Right Quality Control and Analytical Tools to Ensure High Quality Compounds and Successful Screening Results
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TRACK B: Integrating Workflows with Discovery Processes and Teams to Increase CM’s Impact on Research Results
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14.10 Compound Purity And Quality Profiling Case Study
- Analysing random members of over 2000 single synthetic libraries to identify instability in core structures
- Determining structural factors that contribute to bond instability in DMSO
- Using structural motif searches to target potential “low quality” samples within the AstraZeneca compound collection
- Using small sample sets to monitor the progress of a targeted approach to quality management
Ian Sinclair
Global Compound Sciences
AstraZeneca
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14.10 Case Study: An Integrated Sample Submission Solution
- Full integration of lab automation and corporate systems using a pragmatic SOA approach
- Realising significant increase in business efficiency
- Using one application covering the needs of chemists (>400), lab staff and business administrators
Stéphanie Muzzarelli
Manager, Compound Management
Logica Switzerland AG
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14.50 Case Study: Walk-Up Open Access UPLC/MS Systems For QC In The Chemistry Laboratory - Is Global Standardisation Possible?
- Walk-up open access systems for LC/MS analysis of small molecules
- Replacement of classic HPLC by UPLC systems
- Integration of open access chemistry support within a global network
- "OpenLab" solution with NMR, MS and optical spectroscopy support
- Expert advice available via remote desktop connection
- Providing analytical support independent of geographic boundaries
Dr Ingo Muckenschnabel
Laboratory Head, Analytics
Novartis Institutes for Biomedical Research
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14.50 Extending Actelion’s LIMS To Enable Modern Compound Management Processes: A Case Study
- A concept change: Tube tracking, systematic use of 2D coded labware
- Real-time retrieval of parameters to control an automated balance/dissolution platform
- A versatile way to translate complex sample requests into parameters for a single liquid handler protocol
- Controlling a plate replication platform through exchange of XML files with LIMS
Geoffroy Bourquin
Research Expert, Compound Management and Biochemical Assays
Actelion
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15.30 Compound Characterisation Case Study
- Studying compounds using Surface Activity Screening and Fluorescence Spectroscopy
- Limitations of physicochemical profiling of compounds by measurement of logP
- Demonstrating that HTS of the surface activity of compounds provides a useful set of parameters, with excellent correlation to, for instance, the penetration of the blood-brain barrier
- Quantitative HTS assessment of drug-phospholipid complex formation predicts accurately the potency of compounds in causing phospholipidosis, a frequent side-effect of drugs
- Understanding that lipids are important effectors in cellular signalling and targeting these signalling lipids by small molecules
Professor Paavo K.J. Kinnunen
Center for Biomembrane Physics, Medical Biochemistry/Institute of Biomedicine
University of Helsinki
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15.30 Implementing Efficient Compound Workflow And Data Management
- Identifying key challenges in internal workflow from compound acquisition to distribution in a small biopharma company
- Dealing with issues related to commercial software upgrades
- Implementing customised software for compound workflow and data management by different teams
- Increasing performance and implementing QC initiatives - Monitoring and preserving compound quality
Dr Raffaella Brandi
Compound Management & Analysis
Siena Biotech S.p.A.
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16.10 Afternoon Networking Break
16.40 Roundtable Discussions
During each roundtable, the facilitator will present a short case study as a
benchmark for a 60 minute discussion and question session. Attendees will
get a comprehensive review of the surrounding issues, technical capabilities
and differing end-user views. Through discussion with your peers, you will
also get answers to many questions and new innovative ideas to take back
and apply to your compound management work.
**Delegates are welcome and encouraged to bring their own data or study
results or submit them earlier to sarah.haynes@iqpc.co.uk
- A) Improving Quantification and Quality Control of Compounds
- B) Evaluating New Flexible Workstation Models
- C) Working with Colleagues to Enhance Library Content: Identifying,
- Tracking and Acquiring Valuable Samples
- D) Outsourcing Your Compound Management Activities
- E) Post-Merger Integration Challenges
- F) Automated Solid Dispensing and Storage for Compounds
17.40 Roundtable Summaries: Each Roundtable Discussion
Will Be Summarised So All Delegates Can Learn The Most
Interesting And Valuable Points To Each Discussion Subject.
18.10 Chairperson’s Closing Remarks